10-Hydroxycamptothecin ( CAS: 64439-81-2 ) 

10-Hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca

Acuminate (a tree native to mainland China). is a kind of pharmaceutical intermediate, an alkaloid originally

isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and

has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC and HL-60cells.

10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. Compared with

camptothecin (CPT), 10-Hydroxycamptothecin has a longer-lived cleavable complex, and is substantially more

cytotoxic against cancer cells, indicating that the persistence of cleavable complexes may be an essential property

for increasing the likelihood of a collision between the replication fork and a cleavable complex, giving rise to

lethal DNA lesions. [1]10-Hydroxycamptotheci treatment significantly inhibits angiogenesis both in vitro and in

vivo at relatively low concentrations, and this effect is related with induction of apoptosis in human microvascular

endothelial cells (HMEC). 10-Hydroxycamptothecin significantly represses the proliferation of Colo 205 cells at a

relatively low concentration (5-20 nM). 10-Hydroxycamptothecin treatment induces Colo 205 cells arrested in the

G2 phase, and triggers caspase-3-dependent apoptosis. Consistently, oral administration of 10-Hydroxycamptothecin

at a relatively low dose is able to inhibit the growth of Colo 205 xenografts in mice.