8-Hydroxyquinoline (CAS: 148-24-3)

Basic information

8-Hydroxyquinoline is a white or light yellow crystalls or crystal powder, insoluble in

water and ethyl ether, soluble in ethanol, acetone, chloroform, benzene, or dilute acid,

can be sublimated. Less subject to erosion. Low toxicity

8-Hydroxyquinoline is an organic compound with the formula C9H7NO. It is a derivative

of the heterocycle quinoline by placement of an OH group on carbon number 8. This light

yellow compound is widely used commercially, although under a variety of names.

The preparation of the source

It is usually prepared from quinoline-8-sulfonic acid and from a Skraup synthesis from 2-aminophenol.

As a chelating agent

8-Hydroxyquinoline is a monoprotic bidentate chelating agent. Related ligands are the Schiff bases 

derived from salicylaldehyde, such as salicylaldoxime,salen and salicylaldehyde isonicotinoylhydrazone

(SIH). In neutral solution, the hydroxyl is in the protonated form (pKa=9.89) and the nitrogen is not

protonated (pKa=5.13). However, an excited-state zwitterionic isomer exists in which H+ is transferred

from the oxygen (giving an oxygen anion) to the nitrogen (giving a protonated nitrogen cation).

Applications

1. widely used in the determination of metal, and separation.
2. Used as pharmaceutical intermediates,also dyes, pesticide intermediates.
3. Used as precipitation and separation of metal ions of complexing agent and extraction agent.
4. Chemical analysis of complexometric titration indicator.
5. This product is halide quinoline drug intermediates, dye, pesticide intermediates.

Storage transport

Avoid light dry ventilated place

Risk Phrases 

1.R22 to devour the harmful

2.R37 stimulate the respiratory system

3.R38 stimulate the skin

Hazard statements 

Dangerous code:Xn

Danger level:22