Allantoin CAS 97-59-6

Propyl 4-hydroxybenzoate CAS 94-13-3
17/12/2018
Nicotinamide CAS 98-92-0
17/12/2018
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Model: MOS 97-59-6
Brand Name: MOSINTER
CAS No.: 97-59-6
Purity: 98.5-101.0%
Pb: 0.001%max
Appearance: White crystalline powder
Odor: Odorless
Content: 98.5-101.0%
Melting point: 225℃ min
Residue on ignition: 0.1max
Loss on drying: 0.1%max
As: 0.0002%max

Allantoin (CAS: 97-59-6 )

 

Item Index
Appearance White crystalline powder
Odor Odorless
Content 98.5-101.0%
Melting point

(with   decomposition)

225℃ min
Loss on drying 0.1%max
Residue on   ignition 0.1max
Acidity or   alkalinity conforms
Optical rotation conforms
Reducing   substances conforms
Related   substances conforms
As 0.0002%max
Pb 0.001%max

Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin

or glyoxyldiureide. It is a diureide of glyoxylic acid.

Named after the allantois (an amniote embryonic excretory organ in which it concentrates during

development in most mammals except humans and higher apes[vague]), it is a product of oxidation

of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous waste

 is excreted in the urine of these animals. In humans and higher apes, the metabolic pathway for conversion

of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes

used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further

(into ammonia) before excretion. Allantoin is a major metabolic intermediate in many other organisms

including plants and bacteria.

Applications

Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals. Chemically

synthesized bulk allantoin, which is chemically equivalent to natural allantoin, is safe, non-toxic, compatible

with cosmetic raw materials and meets CTFA and JSCI requirements. Over 10,000 patents reference allantoin.

Manufacturers cite several beneficial effects for allantoin as an active ingredient in over-the-counter cosmetics,

including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and

enhancing thedesquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting

cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming

complexes with irritant and sensitizing agents. 

It is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks,

anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other

cosmetic and pharmaceutical products.

Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with

 reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative

stress in chronic illnesses and senescence.

See also

  • Imidazolidinyl urea and diazolidinyl urea, antimicrobial condensation products of allantoin with formaldehyde.

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