Model: | MOS 3094-09-5 |
Place of Origin: | Sichuan,China (Mainland) |
Brand: | MOSINTER |
CAS: | 3094-09-5 |
Molecular Formula: | C9H11O5N2F |
Molecular Weight: | 246.2 |
Appearance: | white crystalline powder |
Specification: | CP/USP/EP |
Assay: | ≥98.5% |
Name: | Doxifluridine |
Identification: | Conform to |
Alias: | flutron |
Doxifluridine ( CAS: 3094-09-5 )
Item | Index |
Molecular Formula | C9H11O5N2F |
Molecular Weight | 246.2 |
Specification | CP/USP/EP |
Appearance | white crystalline powder |
Melting point | 189.0~193.0℃ |
specific rotation | +18.5°- +21.5° |
Identification | Conform to |
PH value | 4.0 – 6.0 |
Assay | ≥98.5% |
Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well.
Uses
Doxifluridine (CAS NO.3094-09-5) is a prodrug of 5-Flurouridine and a fluorinated pyrimidine nucleoside with cytostatic activity. It is used as an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine .
Safety Profile
Hazard Codes:Xi
WGK Germany :2
RTECS:YU7526000
Hazard Note:Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
HazardClass: IRRITANT, IRRITANT-HARMFUL
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