Doxifluridine CAS 3094-09-5

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Model: MOS  3094-09-5
Place of Origin: Sichuan,China (Mainland)
Brand: MOSINTER
CAS: 3094-09-5
Molecular Formula: C9H11O5N2F
Molecular Weight: 246.2
Appearance: white crystalline powder
Specification: CP/USP/EP
Assay: ≥98.5%
Name: Doxifluridine
Identification: Conform to
Alias: flutron

Doxifluridine ( CAS: 3094-09-5 )

Item Index
Molecular Formula C9H11O5N2F
Molecular Weight 246.2
Specification CP/USP/EP
Appearance white crystalline powder
Melting point 189.0~193.0℃
specific rotation +18.5°- +21.5°
Identification Conform to
PH value 4.0 – 6.0
Assay ≥98.5%

Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well.

Uses

Doxifluridine (CAS NO.3094-09-5) is a prodrug of 5-Flurouridine and a fluorinated pyrimidine nucleoside with cytostatic activity. It is used as an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine .

Safety Profile

Hazard Codes:Xi  
WGK Germany :2 
RTECS:YU7526000 
Hazard Note:Irritant 
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin. 
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
HazardClass: IRRITANT, IRRITANT-HARMFUL

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