Pelitinib(CAS: 257933-82-7)

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential

antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth

factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation

and signal transduction and resulting in apoptosis and suppression of proliferation in

tumor cells that overexpress these receptors