Trifluoroacetic Acid CAS 76-05-1

Colorless volatile smoking liquid, similar to acetic acid, with hygroscopic and irritating odor. Influenced by electron absorbing trifluoromethyl, it has strong acidity, which is 100000 times stronger than acetic acid. Melting point – 15.2 ℃, boiling point 72.4 ℃, density 1.5351g/cm3 (1 ℃). It is miscible with water, fluorohydrocarbon, methanol, ethanol, ether, acetone, benzene, carbon tetrachloride and hexane, and can partially dissolve carbon disulfide and alkanes above six carbon. It is an excellent solvent for protein and polyester. It is also an excellent solvent for organic reactions, and the results obtained by Chemicalbook are difficult to obtain in general solvents. For example, when quinoline is catalytic hydrogenated in general solvents, pyridine ring is preferentially hydrogenated, but benzene ring is preferentially hydrogenated in trifluoroacetic acid. Trifluoroacetic acid is decomposed into fluoroform and carbon dioxide in the presence of aniline. It can be reduced to trifluoroacetaldehyde and trifluoroethanol by sodium borohydride or lithium aluminum hydride. Stable above 205 ℃, ester and amide derivatives are easy to hydrolyze, so they can be used to prepare sugar, amino acid and peptide derivatives in the form of acid or anhydride. It is easy to dehydrate to trifluoroacetic anhydride under the action of phosphorus pentoxide.